MACFAST is owned and managed by the Corporate Educational Agency of the Catholic Archdiocese of Tiruvalla, with His Grace Most Rev. Thomas Mar Koorilos as the President and Patron. In the past 76 years this agency has contributed to the establishment of a large number of schools, colleges, hospitals, medical and paramedical institutions throughout the country. Rev. Dr. Abraham Mulamoottil, the founder was the principal of this institution till April 2011.
The administration and the day today management of the College rests with the Principal, Rev. Fr. Pradeep Vazhatharamalayil who is also the Chairman of Radiomacfast 90.4, the campus community radio.
The overall academic and management leadership is given by an Academic Council headed by Padmavibushan Dr. M. S. Valiathan, as Chairman and a Board of Governors headed by Padmabhushan Dr. M. V. Pylee, Kerala's well-known educationalist and management Guru.
Dr. Jose Paul has been appointed as Advisor- Corporate Governance and Strategies, and Dr. Jacob Thomas IAS has been appointed as Advisor- Academic Reforms and Faculty Develpoment.